Lysosomal stabilizing effect of chlorphentermine in the rabbit alveolar macrophage
Identifieur interne : 003859 ( Main/Exploration ); précédent : 003858; suivant : 003860Lysosomal stabilizing effect of chlorphentermine in the rabbit alveolar macrophage
Auteurs : Mark J. Reasor [États-Unis] ; Elizabeth R. Walker [États-Unis]Source :
- General Pharmacology [ 0306-3623 ] ; 1979.
English descriptors
- Teeft :
- Acid hydrolases, Acid phosphatase, Alveolar foam cells, Alveolar macrophage, Alveolar macrophages, Amphiphilic, Amphiphilic drug, Amphiphilic drugs, Anorectic drug, Aryl sulfatase, Blood cells, Cell size, Chlorphentermine, Chlorphentermine administration, Chlorphentermine treatment, Chronic administration, Control rabbits, Difrancesco bickel, Drug administration, Enzyme activity, Foam cells, High levels, Hydrolases, Hypotonic solution, Lamellated inclusions, Latency, Lysis, Lysosomal, Lysosomal acid hydrolases, Lysosomal enzymes, Lysosomal membrane, Lysosomal membranes, Lysosomal properties, Lysosome, Macrophage, Media composition, Myeloid bodies, Normal rabbits, Other species, Percent lysis, Phosphatase, Phospholipidosis, Present study, Pulmonary aspergillosis, Rabbit alveolar macrophages, Specific effects, Tile sample, Toxic appl, Ultrastructural, Ultrastructural alterations, Ultrastructural changes, Warner chilcott.
Abstract
Abstract: 1. Rabbits were injected (i.p.) daily with chlorphentermine (30 mg/kg), 5 days a week for 7 weeks.2. Alveolar macrophages were collected from the lungs of control and treated rabbits by pulmonary lavage.3. When compared to controls, the latencies of the lysosomal acid hydrolases, acid phosphatase and β-N-acetyl glucosaminidase were increased in lysosome-containing fractions from alveolar macrophages of treated rabbits. The same results were obtained when chlorphentermine was incubated in vitro with a lysosomal fraction from macrophages of normal rabbits.4. The increased latency of lysosomal enzymes following chlorphentermine treatment can be explained by the drug's ability to stabilize lysosomal membranes.
Url:
DOI: 10.1016/0306-3623(79)90040-5
Affiliations:
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Reasor</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pharmacology and Department of Anatomy, West Virginia University Medical Center, Morgantown, WV 26506</wicri:regionArea><placeName><region type="state">Virginie-Occidentale</region></placeName></affiliation></author><author><name sortKey="Walker, Elizabeth R" sort="Walker, Elizabeth R" uniqKey="Walker E" first="Elizabeth R." last="Walker">Elizabeth R. Walker</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pharmacology and Department of Anatomy, West Virginia University Medical Center, Morgantown, WV 26506</wicri:regionArea><placeName><region type="state">Virginie-Occidentale</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">General Pharmacology</title><title level="j" type="abbrev">GPH</title><idno type="ISSN">0306-3623</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1979">1979</date><biblScope unit="volume">10</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="83">83</biblScope><biblScope unit="page" to="88">88</biblScope></imprint><idno type="ISSN">0306-3623</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0306-3623</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acid hydrolases</term><term>Acid phosphatase</term><term>Alveolar foam cells</term><term>Alveolar macrophage</term><term>Alveolar macrophages</term><term>Amphiphilic</term><term>Amphiphilic drug</term><term>Amphiphilic drugs</term><term>Anorectic drug</term><term>Aryl sulfatase</term><term>Blood cells</term><term>Cell size</term><term>Chlorphentermine</term><term>Chlorphentermine administration</term><term>Chlorphentermine treatment</term><term>Chronic administration</term><term>Control rabbits</term><term>Difrancesco bickel</term><term>Drug administration</term><term>Enzyme activity</term><term>Foam cells</term><term>High levels</term><term>Hydrolases</term><term>Hypotonic solution</term><term>Lamellated inclusions</term><term>Latency</term><term>Lysis</term><term>Lysosomal</term><term>Lysosomal acid hydrolases</term><term>Lysosomal enzymes</term><term>Lysosomal membrane</term><term>Lysosomal membranes</term><term>Lysosomal properties</term><term>Lysosome</term><term>Macrophage</term><term>Media composition</term><term>Myeloid bodies</term><term>Normal rabbits</term><term>Other species</term><term>Percent lysis</term><term>Phosphatase</term><term>Phospholipidosis</term><term>Present study</term><term>Pulmonary aspergillosis</term><term>Rabbit alveolar macrophages</term><term>Specific effects</term><term>Tile sample</term><term>Toxic appl</term><term>Ultrastructural</term><term>Ultrastructural alterations</term><term>Ultrastructural changes</term><term>Warner chilcott</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: 1. Rabbits were injected (i.p.) daily with chlorphentermine (30 mg/kg), 5 days a week for 7 weeks.2. Alveolar macrophages were collected from the lungs of control and treated rabbits by pulmonary lavage.3. When compared to controls, the latencies of the lysosomal acid hydrolases, acid phosphatase and β-N-acetyl glucosaminidase were increased in lysosome-containing fractions from alveolar macrophages of treated rabbits. The same results were obtained when chlorphentermine was incubated in vitro with a lysosomal fraction from macrophages of normal rabbits.4. The increased latency of lysosomal enzymes following chlorphentermine treatment can be explained by the drug's ability to stabilize lysosomal membranes.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Virginie-Occidentale</li></region></list><tree><country name="États-Unis"><region name="Virginie-Occidentale"><name sortKey="Reasor, Mark J" sort="Reasor, Mark J" uniqKey="Reasor M" first="Mark J." last="Reasor">Mark J. Reasor</name></region><name sortKey="Walker, Elizabeth R" sort="Walker, Elizabeth R" uniqKey="Walker E" first="Elizabeth R." last="Walker">Elizabeth R. Walker</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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